Digital labor is reshaping how work gets done. As AI agents evolve from task automation to true knowledge partners, enterprises are redesigning workflows, roles, and operating models to support hybrid human–AI teams. This guide explains what digital labor transformation is, why it is accelerating now, and what the latest research from the Agentic AI Futures Index reveals about maturity, readiness, and the growing execution gap. It also outlines the actions leaders must take to build trusted, scalable, and ROI-positive digital labor programs.